Fluoropyrimidine-induced cardiac toxicity: challenging the current paradigm

Challenging the pressure sore paradigm.

This study determines the effectiveness of a new low-unit-cost support system in patients at very high risk of developing pressure sores. In a prospective randomised controlled trial, a low-pressure inflatable mattress and cushion system (Repose) was compared to a dynamic support mattress (Nimbus II) used in conjunction with an alternating-pressure cushion (Alpha TranCell) in 80 patients with f...

Pathogenesis of Atopic Dermatitis: Current Paradigm

Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction and chronic pruritus. In this review, recent advances in the pathogenesis of AD are summarized. Clinical efficacy of the anti-IL-4 receptor antibody dupilumab implies that type 2 cytokines IL-4 and IL-13 have pivotal roles in atopic inflammation. The expression of IL-4 and IL-13 as well as type 2 chemokines such a...

Challenging the current paradigm of melanoma progression: brain metastasis as isolated first visceral site.

Melanoma brain metastasis that develops as the isolated first visceral site challenges the current paradigm of tumor progression in which brain metastasis is regarded as the final stage. Here we test the hypothesis that melanoma patients who develop brain metastasis as the isolated first visceral site have distinct clinicopathological features at the time of primary melanoma diagnosis. Cutaneou...

Challenging Current Medical Misconceptions

Charles H., a 56 year old computer store manager, came to his local emergency room, complaining of vague chest discomfort present for about 4 h. Based on an absence of prior history of cardiovascular disease, a normal cardiovascular examination and electrocardiogram (ECG), and a failure to report any pain relief following the administration of sublingual nitroglycerin, the patient was discharge...

Toxicity Testing and the Toxicity Testing and the Current Situation in IRAN